In the summer of 1916, the Missionary Sisters Servants of the Holy Spirit bought a large house on 60 acres of woodland in what was then rural Hyattsville—not a single building stood between Hyattsville and Washington, DC—to provide a home for religious sisters who were studying at Washington's Catholic University. They also wanted to enjoy communal living in caring and spiritually nurturing surroundings.

To pay for the costs of maintaining the home and caring for themselves, they invited ladies who wished to live their remaining years in a religious environment to join them.

In the 1960's, after expanding and renovating the home several times, the Sisters decided they wanted to extend their caring hearts to the sick and the infirm, and Sacred Heart home became a Medicaid-licensed nursing home.

In 1998 the Missionary Sisters Servants of the Holy Spirit transferred sponsorship and ownership of the home to the Sisters Servants of Mary Immaculate, whose mission includes caring for those who can no longer care for themselves.